Meredith: I've moved on. So don't give me that look.
Derek: what look?
Meredith: That look. Our look. I'm over you.
Derek: I'm over you too.
Meredith: you are?
Derek: no.
Meredith: oh, well. I am. Over you.
Derek: I'm over you too.
Meredith: you just said- shut up.

Four hundred years ago, another well-known English guy had an opinion about being alone. John Donne. He thought we were never alone. Of course, it was fancier when he said it. "No man is an island entire unto himself." Boil down that island talk, and he just meant that all anyone needs is someone to step in and let us know we're not alone.

How do you know how much is too much? too much too soon, too much information, too much fun, too much love, too much to ask? and when is it all just too much to bear?

Meredith: Don't look at me like that, like you've seen me naked.
Derek: It's not the chase.
Meredith: What?
Derek: You and me. It is not the thrill of the chase. It's not a game. It's… it's your tiny ineffectual fists. And your hair.
Meredith: My hair?
Derek: It smells good. And you're very, very ballsy. It keeps me in line.
Meredith: I'm still not going out with you.
Derek: You say that now.

Dr. Bailey: All you people ever think about is how to get into somebody's pants. You're nasty. [slaps George] That's why you got syphilis.

Sometimes reality has a way of sneaking up and biting us on the ass. And when the dam bursts, all you can do is swim. The world of pretend is a cage, not a cocoon. We can only lie to ourselves for so long. We are tired. We are scared. Denying it doesn’t change the truth. Sooner or later, we have to put aside our denial and face the world, head on, guns blazing. Denial. It’s not just a river in Egypt. It’s a freakin’ ocean. So how do you keep from drowning in it?

Pain comes in all forms. The small twinge, a bit of soreness, the random pain, the normal pains we live with everyday. Then there's the kind of pain you can't ignore. A level of pain so great that it blocks out everything else... makes the rest of the world fade away, until all we can think about is how much we hurt. How we manage our pain is up to us. Pain, we anestitize, ride it out, embrace it, ignore it. and for some of us the best way to manage pain is to just push through it

Cristina: You are eight feet tall. Your boobs are perfect. Your hair is down to there. If I was you I would just walk around naked all the time. I wouldn't have a job, I wouldn't have any skills, I wouldn't even know how to read. I would just be... naked.
Izzie: It's makeup. It's retouching.
Cristina: You get that we hate you, right?

Meredith: After all this time, all your warnings about me sleeping with my boss and you're doing the same exact thing.
Cristina: Oh, it's not the same thing.
Meredith: It's the exact same!
Cristina: No, it's not. You and McDreamy are in a relationship.
Meredith: And you and Burke are in?
Cristina: Switzerland. It's very neutral there and they make very nice watches

When you were a kid, it was Halloween candy. You hid it from your parents and you ate it until you got sick. In college, it was the heavy combo of youth, tequila and well, you know. As a surgeon, you take as much of the good as you can get because it doesn't come around nearly as often as it should. 'Cause good things aren't always what they seem. Too much of anything, even love, is not always a good thing.

Christmas makes you want to be with people you love. I'm not saying this to hurt you, or because I want to leave you, because I don't. Meredith wasn't a fling. She wasn't revenge. I fell in love with her. That doesn't go away because I decided to stay with you.

There's something to be said about a glass half full. About knowing when to say when. I think it's a floating line. A barometer of need and desire. It's entirely up to the individual. And depends on what's being poured. Sometimes all we want is a taste. Other times there's no such thing as enough, the glass is bottomless. And all we want, is more.

Alex: Why are you helping me?
Izzie: [yells] 'Cause it's what Jesus would freaking do!

But as human beings, sometimes it's better to stay in the dark, because in the dark there may be fear, but there's also hope

Communication. It's the first thing we really learn in life. Funny thing is, once we grow up, learn our words and really start talking the harder it becomes to know what to say. Or how to ask for what we really need.